Effect of new preventive medicine on pentylenetetrazol-induced kindled mice using database analyses
نویسندگان
چکیده
منابع مشابه
Ivabradine Reduces Seizures in Pentylenetetrazol- Kindled Mice
Methods: Forty Mice were randomly allocated into 4 equal groups; control, PTZ, diazepam (4mg/kg) and ivabradine (10 mg/kg) groups. Kindling model was produced by repeated i.p. administration of PTZ (40mg/kg), every other day for 9 days. Repeated PTZ treatment progressively increased the seizure score with the maximum score reached on day 9. Diazepam and ivabradine were administered intraperiton...
متن کاملMontelukast reduces seizures in pentylenetetrazol-kindled mice.
Cysteinyl leukotrienes (CysLTs) have been implicated in seizures and kindling; however, the effect of CysLT receptor antagonists on seizure frequency in kindled animals and changes in CysLT receptor expression after pentylenetetrazol (PTZ)-induced kindling have not been investigated. In this study, we evaluated whether the CysLT1 inverse agonist montelukast, and a classical anticonvulsant, phen...
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Sildenafil is the first marketed phosphodiesterase 5 inhibitor for the treatment of erectile dysfunction and recently, for pulmonary hypertension. While the treatment was found to be highly effective, several adverse effects are associated with this compound. Among numerous central nervous system-related untoward effects, proconvulsant activity was reported. The purpose of this study was to ass...
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Background: There have been some reports about the possible N-methyl-D-aspartate (NMDA) antagonist activity of Guaifenesin. As drugs with a similar structure to Guaifenesin (i.e. Felbamate) and those with NMDA antagonist activity have been clinically used as anticonvulsants, the aim of this study was to determine whether Guaifenesin has an anticonvulsant effect in an animal model of seizure. ...
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ژورنال
عنوان ژورنال: Proceedings for Annual Meeting of The Japanese Pharmacological Society
سال: 2020
ISSN: 2435-4953
DOI: 10.1254/jpssuppl.93.0_1-ss-34